| dc.description.abstract | Staphylococcus aureus has been recognized as one of the five most common causes
of infections in humans. Meticillin-resistant staphylococci have been reported with
increasing frequency worldwide. In this study, S. aureus was isolated from healthy
people in Ho Chi Minh City, Viet Nam and determined the its drug susceptibility to
four commonly used antibiotics including amoxicillin, cefotaxime, oxacillin, and
vancomycin by using disc diffusion technique. A total of 306 volunteers, over 18
years old, were surveyed for nasal carriage of methicillin resistant Staphylococcus
aureus. The overall prevalence of S. aureus nasal carriage among the healthy people
was 16.34%. Rate of MRSA found in these isolates was 10%. Antibiotic sensitivity
test showed that most of the isolates were resistant to amoxicillin (88%) few
resistant to cefotaxime (2%) and none resistant to vancomycin. Strikingly, around
10% of these isolates were resistant to oxacillin indicating that they were MRSA
strains. This rate is relatively high in community which should be taken into account
for new antibiotic therapy in treating staphylococcal infection. While PantonValentine Leukocidin (PVL) gene was absent in all isolates, staphylococcal
enterotoxin A gene has a much more common frequency in commensal S. aureus
(16%). In conclusion, our data provided essential information on the frequency of
methicillin resistant S. aureus in community as well as their two important virulence
factors. This information would aid clinicians in prescribing antibiotics for treatment
of community- acquired (CA) S. aureus infections.
Key words: Meticillin-resistant Staphylococcus aureus, antibiotic resistant, nasal
carriage, Ho Chi Minh City, Staphylococcal Enterotoxin A, Panton- Valentine
Leukocidine. | en_US |
