| dc.description.abstract | Solid dispersion is one of the most conventional methods to improve the solubility of
poorly water-soluble drugs, however it also has some limitations. The purpose of this research is
to develop a method to increase dissolution rate of poorly water-soluble drug base on the
adsorption of solid dispersion (SD) on fumed silica. Solid dispersion of Ibuprofen with different
ratio of Poloxamer 407 and Aerosil® were prepared by melting method and mechanical mixing.
Dissolution test was conducted using conventional paddle method in imitative gastric fluid.
Physicochemical characterizations like PXRD and FTIR was performed to clarify the role of
polymer and Aerosil®. Also, scanning electron microscopy (SEM) images were taken to
determine the morphologic change of samples. Contact angle was measured to determine the
wettability of formulations. The drug release data was measured by UV-vis spectrophotometer.
The result showed that dissolution rate is proportional with the amount of Poloxamer 407 but
only with exact amount of Aerosil® can improve the dissolution of SDs, the optimized
formulation is F5 with the ratio of 1:3:1.5 of drug, polymer and Aerosil®. Moreover, Poloxamer
407 is proved to be the suitable polymer for this research comparing with two different polymers
Poloxamer 188 and PEG 6000, in terms of drug release, morphologic characteristic as well as
contact angle. Overall, the adsorption of solid dispersion on Aerosil® is proved to be feasible for
immediate release formulation of Ibuprofen.
Keywords: solid dispersion, adsorption, Aerosil®, dissolution, FTIR, PXRD, contact angle, SEM | en_US |
