| dc.description.abstract | In this study, Fucoidan and oleic acid were conjugated together as a carrier the
systems used to deliver the poorly water-soluble anti-cancer drug. Transmission Electron
Microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FT-IR) were used to
analyze the conjugate. Drug nanoparticles were prepared by solvent evaporation method.
In this study, two formulas were examined. The first one loaded Curcumin with Iron
oxide nanoparticles and the other one loaded Paclitaxel with iron oxide nanoparticles into
the conjugates. Amount of Curcumin, Paclitaxel and Fucoidan was quantified by direct
methods. Samples were collected at 1, 6, 12, 24, 36, 48 and 60 hours of dissolution time
from in vitro release. The drugs loaded into the conjugates were dissolved into the
simulated normal tissue (pH 7.4) and the simulated tumor (pH 4.5). The morphology
structure and size was investigated by the Transmission Electron Microscope (TEM) and
a scanning electron microscope (SEM). Powder X-ray diffraction (PXRD) used to
examine crystal structure of nanoparticles. High-performance liquid chromatography
(HPLC) method was used to determine concentration of Curcumin and Paclitaxel after
dissolution test. Fucoidan concentration was determined by conductometric titration
method. The samples nanoparticles obtained are capable of loading poorly water-soluble
drug anticancer drugs. Concentrations of Curcumin release in pH 4.5 and pH 7.4 are the
same. Paclitaxel's concentrations release in acidic environment is lower than normal
environment. Concentration of Fucoidan release in pH 4.5 is higher than pH 7.4. Finding
effective drug delivery system has the ability releasing two anticancer drugs as Fucoidan and Curcumin or Paclitaxel. Simultaneously, with iron nanoparticle can help to improve
diagnostic efficiency of MRI images. | en_US |
