| dc.description.abstract | Traditionally, nearly 40% of the new chemical entities identified by pharmaceutical
industry screening programs have failed to be developed because of poor water-solubility,
which makes their formulation difficult or even impossible. The solubility issues
complicating the delivery of these new drugs also affect the delivery of many existing drugs.
This research study aims to develop a newer method that is the precipitation from the solid
dispersion forming a system for drug to reduce the particle size to nanoparticle and to achieve
a better drug release performance. Solid dispersion – precipitation system (melting and
solvent method) with different ratio of polymers (PEG 6000/Poloxamer 407) were prepared
using spray drying/freeze drying to modulate the drug crystal and particle size.
Physiochemical characterizations, including power X-ray diffraction and Fourier Transform
infrared spectroscopy were performed to elucidate the role of the carriers in the formulations.
Fortunately, this system not only reduces the drug crystallinity, the drug particle size but also
resulted in an improvement in dissolution profile. This work may contribute to dissolution
enhancement of poorly water-soluble drugs with solid dispersion – precipitation method.
Keywords: solid dispersion, precipitation, nanoparticle, crystallinity, enhance dissolution
rate | en_US |
