| dc.description.abstract | Hydrogels have been used widely in surgery and wound healing as adhesives
thanks to their rapid polymerization and strong adhesion. The aim of this study is to
synthesize a new hydrogel – Hyaluronan/Poly (vinylphosphonic acid)/Chitosan
(HA/PVPA/CS) hydrogel – with characteristics that can be applied as bioadhesive for
skin wound healing. The hydrogel was synthesized by chemical crosslink method; the
results showed that it was stable at pH up to 5.5 and its optimized ratio in volume of HA
(1% w/v): PVPA (10% w/v): CS (2% w/v) was 5:2:40. Microscopic observation
presented its 3 dimensional network structure formed by random arrangement of
hydrogel’s fibers. Fourier transform infrared spectroscopy (FT-IR) and Nuclear magnetic
resonance (NMR) spectra indicated the presence of ester bonds, and ionic interaction in
its chemical structure. Swelling and degradation results proved that the hydrogel had a
fast swelling rate and a short degradation time. Besides, the hydrogel also had elastic
property than can mimic skin surface to cover the wound. Additionally, the antibacterial
results showed that the hydrogel performed antibacterial activity against E. coli. Lastly, it
possessed positive effect in enhancing skin wound healing process in in vivo murine
implantation experiments. In conclusion, with those characteristics, HA/PVPA/CS
hydrogel was a potential material to apply as bioadhesive in skin wound healing.
KEY WORDS: Hyaluronan, Poly (Vinylphosphonic acid), Chitosan, hydrogel,
bioadhesive, bioglue, skin wound healing | en_US |
