Preparation and characterization of prednisolone-loaded solid lipid nanoparticles by ultrasonication method

Abstract

The aim of this study is to improve dissolution rate of poorly water soluble drug Prednisolone by using Solid lipid nanoparticles and to design a buccal delivery dosage form through creating buccal tablets. Solid Lipid Nanoparticles (SLNs) were prepared by ultra-sonication method to load API into vehicle. The evaluation of completed sample was carried out by testing their uniformity, stability, particle size measurement. The buccal tablets collected from lyophilization process was characterized by dissolution studies, microenvironment pH, mucoadhesion time and their swelling index. In particle size measurement, amount of stearic acid showed an important tendency that the more quantity of solid lipid, the larger particle size was formed. Polysorbate 80 (Tween 80) showed better results than the POX 188. The power and ultra-sonication time were also crucial factors in creating nanoparticles. The successful formulas showed improved percentage of drug release of 80% and 83% after 8 hours of testing, which followed immediate and sustained release pattern respectively. Besides, an adaptable surface pH of 6.77, long mucoadhesion time, satisfactory permeation and reasonable sweeling index pointed out suitable conditions for buccal tablet designing without causing any irritation. Keywords: Prednisolone, Solid lipid nanoparticle, sustained release, buccal tablet, freeze-dry