Preparation and characterization of curcumin - loaded solid lipid nanoparticles by ultrasonication method

Abstract

The study was aim to evaluate formation and characterization Curcumin nanoparticle, which is the stable form used in the skin‘s improvement through topical administration. The experiments were prepared into 2 main parts. At the first, using ultrasonication method was the purpose to create the nanosize for Curcumin particles. In the optimal conditions, 0.03% Curcumin (w/w) and 5% Tween 80 (w/w), the variation in the amount of stearic acid, various in ultrasonication time and power had profound effects on the Curcumin loading capacity, the mean particle size, and size distribution and drug release. The second part of the experiment were showed by combination between solid dispersion and solid lipid nanoparticle to create the nano smaller size for Curcumin particles, leading to increasing permeability of Curcumin and drug release through modeled skin- Cellulose Acetate membrane. In this part, two methods (M1 and M2) of melting method were used to investigate how the particle size and drug release of Curcumin were affected by temperature point in the incorporation of solid dispersion and solid lipid nanoparticles preparations. Besides, ratios between hydrophobic drug and hydrophilic polymer also influenced Curcumin released. As the result, there would be a defined balance between the ratios of components in solid lipid nanoparticles preparation and between the amount of our API and polymer in solid dispersion process with the suitable point time in combination of SD-SLN to get the highest Curcumin release. To elucidate the mechanism of drug release from SLN and SD, the structural behaviors of drug were characterized by instrumental methods such as the Powder X-ray Diffraction (PXRD), Fourier Transform Infrared spectroscopy (FTIR). Besides, cream is known as ix conveniently safe way helping increase the permeability through the skin, which was used in this research. In here, the reduced in the particle size become the promising field for next step in the continued research. Keywords: Curcumin, solid dispersion (SD), solid lipid nanoparticles (SLN), cream, topical administration.