Characterization and mechanism of solid lipid nanoparicles- based tablet for buccal delivery

Abstract

The aim of the present research was to investigate the characterization and mechanism of solid lipid nanoparticles-based tablet for buccal delivery by following the previous thesis report in improvement solubility and sustained release of hydrophobic drug (Prednisolone) of SLPs. Prednisolone (PSL) loaded SLPs was conventionally prepared by ultrasonication technique. Freeze-drying method was used to convert solid lipid nanoparticles solution into solid dosage form for buccal delivery system by using Mannitol such as cryoprotectants. The combination between cryoprotectant, different polymers (HPMC 4000, Carbopol) and SLPs-based also created successful in improving drug release. All formulations drug release were over 80% after 6 h of testing, which respectively followed immediate and sustained release pattern. However, the different polymer in formulations made different mucoadhesion time and drug permeated. HPMC 4000 showed higher drug permeated but shorter mucoadhesion time than Carbopol. Besides, a scanning electron microscopy test (SEM), swelling and erosion, paticle size and zeta potential also pointed out the mechanism for buccal tablet designing with reaching highest effective for human body. The success of this work would point out a good strategy for improving bioavailability of poorly water-soluble drugs by buccal delivery. Keywords: Prednisolone, solid lipid nanoparticle, buccal tablet, sustained release, polymer.