| dc.description.abstract | Ensete glaucum is considered as traditional medicines with many therapeutic effects on human
health with properties to enhance the life quality. The present study targeted at investigating the
in vitro antioxidants properties of E. glaucum seed hydroalcoholic extract through DPPH,
ABTS, reducing power assays, also evaluating the xanthine oxidase inhibitory capacity and
hypouricemic activity in potassium oxonate-induced hyperuricemic mice model. The results
showed that the extract contains significant amounts of total polyphenol and flavonoid contents
which were 1.07 mg GAE/g DW and 0.23 mg QE/g DW, respectively. Also, it released the
contribution as antioxidants by the results of DPPH, ABTS and reducing power assays, the IC50
were equivalent to 2.32, 2.84 and 4.69 mg dried seeds/mL rice wine, respectively. For the
xanthine oxidase inhibitory activity, the extract also showed the potential inhibiting ability by
the IC50 which was equivalent to 15.7 mg dried seeds/mL rice wine. Finally, the in vivo
hyperuricemic mice model with pretreatment of repeated doses-14 days of the extract (6 mL/kg
and 12 mL/kg respectively) rose uric acid levels of mice significantly, compared to the groups
of non-alcoholic consuming mice. Combining all the results, the study has demonstrated that
E. glaucum hydroalcoholic extract from seeds confirmed the antioxidants potential but the
preventing and treating potential of hyperuricemia were not shown as expectation. | en_US |
