Study On The Biocompatibility Of Ti Implant On An In Vivo Rabbit Model

Abstract

The most advanced material for biomedical implant is the Ti-6Al-4V. However, there are still problems with the tissue-implant contact. The most prominent disadvantage of Ti implants, which has been insufficiently received in-depth studies, is the biocompatibility on in vivo animal model. In this study, the implants, which have been already manufactured by additive manufacturing methodology applying the SLM technique (Ti-SLM) and then coated with PCD (Ti-SLM-PCD), are investigated on in vivo rabbit model. The characterization of Ti implants provides the basic understanding of their behaviors to evaluate the biocompatibility and osseointegration potential. Subsequently, the CBC is conducted to assess the toxicity of the inserted implants. Then, the measurement of biomechanical strength and histological staining are performed to assess the boneimplant binding and histological status of bone regeneration. The CBC result shows no signs of toxicity, and the measurement of biomechanical strength reveals the highly significant enhancement of bone-implant binding. The histological analysis indicates the morphologically and structurally healthy condition of freshly-formed bone tissues. The treatment of Ti implants for the tibia bone defect is a promising approach at in vivo experimental level.