Application Of Low-Power Semiconductor Led Using Red-Light Wavelength In Hair Loss Treatment On Mice Model

Abstract

Objectives: Hair loss affects up to 70% of men over the age of 50 and 40% in women older than 70 years, thus, affecting the psychosocial, mental health, and quality of life of the patient. Therefore, this study investigated the hair growth-promoting activity of Low-laser light therapy on a mouse model of testosterone-inhibition hair growth. Materials and methods: Low-laser light therapy device using visible red-light wavelength 655 nm delivered mean power set at 2.0 mW/cm2 for 20 minutes. Male Swiss albino mice, 6-8 weeks old were shaved on the back and then hair growth inhibition by injecting testosterone dose of 1.0 mg/0.1 mL once a day, five days a week during the experiment. Mice were treated once every other day and with Perilla extract evenly once a day for 35 days. Hair growth was evaluated by visual observation and histological study. Results: Combined-treated group had nearly the same hair growth point as the Healthy group (3.8 >< 4.0 at the end of the experiment). The duration of treatment in the Combined-treated group was about 35% faster than in the Disease group compared to 28% by Light-treated-only group. Conclusions: Low-laser light therapy stimulated hair growth in male Swiss albino mice model of hair growth inhibition by testosterone. This approach brings up a more optimal treatment direction for the patient. Besides, the combined treatment method gives better results than the conventional treatment, therefore, future work includes researching on combination treatments for hair loss.