Non-Invasive Glucose Measuring Utilizing Polarization Technique

Abstract

Diabetes, is one of the most prevalent illnesses in the world, impacting patients' health, appearance, and way of life. Although there are numerous invasive and less invasive gadgets on the market for diabetics, the treatment of diabetics still faces many obstacles and does not satisfy all of the needs. Due to the vast potential of non-invasive applications in the real world, scientists have done several research on developing a noninvasive device for commercialization. This study focuses on a unique method to light polarization in which circular birefringence (CB) is stressed since previous studies have shown the importance of this property. A 650 nm laser source, two 90-degree polarizing prisms, a sample cuvette, and photon detectors were used to monitor and study the optical properties of human plasma samples containing D-glucose at concentrations ranging from 0 to 1M. Furthermore, the ACCU-CHEK is a trustworthy invasive blood glucose meter for calibrating experimental data. Experiments were conducted on a total of 13 blood samples containing D-glucose solution mixed with blood from the Institute of Malaria - Parasitology - Entomology Ho Chi Minh City, with each sample being measured six times. The experimental findings show a substantial linear relationship between plasma CB and D-glucose levels in human blood. The experimental findings reveal a substantial linear association between plasma CB1 concentration and D-glucose in human blood, which will serve as a solid foundation for the development of a non-invasive diabetes monitoring device. To achieve more consistent and precise findings, testing will be undertaken in vivo utilizing mouse models or more specific specimens in the future.