Preparing And Evaluating The Anti Inflammatory Ability Of Curcumin Loaded Chicken Egg Protein Nanoparticles Oral Drug Delivery

Abstract

Colitis is prevalent and burdensome due to IBD. However, the treatment method's usage of anti-inflammatory medicines has major drawbacks. Most long-term anti-inflammatory medications are poorly absorbed and bioavailable. Thus, drugs lose potency and worsen side effects. In this research suggests a medication delivery technique for treating IDB or for oral medicine and treatment delivery. EPN was created by cold gelation and homogenization by the self-assembled protein method, then used to transport curcumin and generate a polyelectrolyte-based nanosystem named Cur@EPN(P). This nanosystem is ideal for oral medication delivery and regulated release due to its pH-sensitivity. Cur@EPN(P) was tested for antioxidant, antiinflammatory, and cytotoxic effects. EPN and Cur@EPN(P) were synthesized with particle sizes of 100 and 220 nm and positive potential. EPN loading curcumin enhances solubility, noncytotoxicity, and anti-inflammatory, free radical scavenging, and reducing power. In a RAW 264.7 macrophage cell culture treated with LPS, Cur@EPN(P) depletes nitric oxide to reduce inflammation. TMC and Alginate surface modification improved stability and release at neutral pH.