| dc.description.abstract | Oxidative stress and inflammation are commonly present in many chronic diseases.
Such responses are well correlated with pathophysiological processes. The inflammatory
process can lead to oxidative stress, and vice versa, via the activation of numerous
pathways. As a result, medicines having antioxidant and/or anti-inflammatory properties
are extremely beneficial in the treatment of several diseases.
In this study, a ROS scavenging agent was successfully synthesized in the form of
silica-contain redox nano particle (siRNP). Additionally, a control nanoparticle (CNP) with
similar structure except the nitroxide radical TEMPO was used to prove the property of
siRNP. Both nanoparticles were synthesized through dialysis of respective copolymer
powder, and the characterization was conducted by dynamic light scattering (DLS). siRNP
displayed a fair potential in antioxidant and anti-inflammatory properties as a result of
several in vitro and in vivo experiments. Moreover, the protective effect of siRNP was
assessed by using zebrafish copper/H2O2-induced model, and it showed a prominent
antioxidant effect by lower the amount of ROS through radical scavenging activity. Taken
together, the results indicated that siRNP contains potent antioxidant and antiinflammatory properties and can be useful for treating a variety of inflammatory diseases. | en_US |
