Fabrication And Characterization Of Electrospun Polycaprolactone/Halloysite Nanotubes Hydrophobic Nanofibrous Membrane For Hemostatic Wound Dressing

Abstract

Electrospinning technique is used to fabricate the nanofibrous scaffold that simulates the surface of the rose petal's architecture. Halloysite nanotube (HNT) – a nanoclay material - is used as the hemostatic material was blended to the polymeric solution to create the PCL/HNT electrospun membrane scaffold. Different ratios of HNT were used for the fabrication. After characterizing the physical property, samples are then compared with cotton gauze (CG) and a commercialized gauze - QuikClot® First Aid Advanced Clotting Gauze (ACG) to investigate the hemostatic capacity. The fabricated PCL/HNT enhances the PCL fiber in physical and chemical grade while performing great blood coagulation without hemolysis. Furthermore, SEM images of the blood – material interaction show a sufficient amount of red blood cells attached on the fiber surface with the formation of fibrin meshes indicate that the fabricated surface morphology with the increases of HNT content upto 60 wt % (compared to PCL) is promising for rapid hemostatic wound dressing application.