| dc.description.abstract | Wound healing is an issue that receives a lot of attention, and there is research to
develop drugs to heal wounds. People often use silver nanoparticles with good antibacterial
properties and water-soluble chitosan as an anti-inflammatory support and for wound recovery.
However, chitosan has poor bioavailability because it is difficult to dissolve, so people use
careful techniques to reduce the molecular weight of chitosan into water-soluble chitosan. This
study focuses on developing a gel formulation containing silver nanoparticles with watersoluble chitosan for wound healing applications. The gel concentration was normalized at 4%
using Carbopol 940, and the gel produced from AgNPs and WSC was evaluated for gel
physical properties, antibacterial and anti-inflammatory properties, and toxicity. The gel-sliver
nanoparticles and water-soluble chitosan were evaluated fairly well in terms of their physical
properties because the gel's stability in the environment was still changed after 48 hours.
Regarding antibacterial activity, AgNPs-WSC gel is highly appreciated because of the presence
of inhibition zones in E.coli, S.aureus, and P.aeruginosa. | en_US |
