| dc.description.abstract | Curcumin hinders the activation of nuclear factor-kappa B (NF-κB), leading to a
decrease in the generation of inflammatory cytokines. It inhibits the function of
inflammatory enzymes such as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX),
resulting in reduced production of pro-inflammatory mediators. However, its application
has remained challenging due to its low aqueous solubility, and poor bioavailability, hence,
nanoemulsion may enhance curcumin's solubility in water and enhance its bioavailability.
The study involves producing nanoemulsion using coconut oil as the lipid phase, Tween
80 as the surfactant, and PEG-b-PMNT as a stabilizing and redox-responsive agent. The
PEG-b-PMNT component enhances the stability of the nanoemulsion and creates a redoxactive environment, which may boost the anti-inflammatory properties of curcumin. The
physicochemical characteristics of the nanoemulsion, such as droplet size, polydispersity
index (PDI), encapsulation efficiency, and drug release, were assessed. The findings
showed superior performance compared to a control nanoemulsion without PEG-b-PMNT
and free curcumin. In addition to oxidation, an inflammatory response, several assays such
as reducing power test, ABTS assay, and DPPH assay are used to assess the antioxidant
properties of PNE@CUR. In addition, the anti-inflammatory properties of nanoemulsion
are shown by regulating the production of nitric oxide (NO) from lipopolysaccharide and
reactive oxygen species (ROS) assay. According to the findings of this project, the effects
of combining curcumin, PEG-b-PMNT, and coconut oil in a nanoemulsion formulation
may provide a foundation for developing new anti-inflammatory nanoformulations with
enhanced therapeutic effectiveness. | en_US |
