| dc.description.abstract | Microneedles are a promising technology in the medical field due to their ability to
deliver drugs painlessly and effectively through the skin. However, current microneedle
manufacturing methods in Vietnam face challenges such as high material wastage,
extensive labor requirements, and prolonged production times. The thesis presents the
design and fabrication of an auto-dispenser hydrogel machine aimed at enhancing the
production of microneedles for transdermal drug delivery systems. The novel autodispenser technology developed in this thesis addresses these issues by significantly
reducing material wastage and labor requirements while also decreasing production time.
A critical aspect of this process is the relationship between filling duration, material
viscosity, and PDMS mold thickness. A critical aspect of this process is the relationship
between filling duration, material viscosity, and PDMS mold thickness. The optimized
dispensing process also accounts for these factors, achieving precise control over
microneedle geometry. The integration of chitosan as a biodegradable material further
ensures the sustainability and biocompatibility of the microneedles. Our results
demonstrate that higher viscosity materials and thicker PDMS molds require adjustments
in dispensing parameters to minimize filling duration without compromising microneedle
quality. This method not only improves manufacturing efficiency but also enhances the
mechanical strength and performance of microneedles, making them highly suitable for
diverse biomedical applications. This innovative approach marks a significant
advancement in microneedle production technology, offering a scalable and cost-effective
solution for the pharmaceutical industry in Vietnam and beyond. | en_US |
