| dc.description.abstract | Five compounds including quercetin (AC01), asparagine (AC02), sucrose (AC03), β- Sitosterol-3-O-β-glucopyranoside (AC04) and β- Sitosterol (AC05) were isolated from the methanol extract from tuber of Asparagus cochinchinensis (Lour.) Merr. collected in Ba Ria – Vung Tau Province of Vietnam. Their structures were elucidated by NMR (1D and 2D-NMR). Among them, quercetin (AC01) had strong antioxidant activity with IC50= 14.52±2.11 µg/mL (DPPH method, compared to standard vitamin C with IC50 = 10.49±2.00 µg/mL). Besides, quercetin (AC01) was evaluated cytotoxicity against the human ovary HeLa cancer cell line with IC50 = 5.78±0.36 µg/mL (SRB method, compared to standard Camptothecin with IC50 < 1 µg/mL)and lung NCI – H460 cancer cell line with IC50 = 12.57±1.19 µg/mL (SRB method, compared to standard Camptothecin with IC50 < 0.01 µg/mL).
Keywords: Asparagus cochinchinensis, quercetin, asparagine, sucrose, β- Sitosterol-3-O-β-glucopyranoside, β- Sitosterol, DPPH, HeLa, NCI-H460, SRB. | en_US |
