| dc.description.abstract | The aim of this study was to examine and evaluate anti-inflammatory
properties of
Calendula officinalis. Calendula officinalis
leaf extract – loaded
cream was prepared and assayed for antimicrobial and anti-inflammatory
activity. The formulation was screened for its antimicrobial activity using agar
well diffusion method.
Staphylococcus aureus, Escherichia coli
, and
Pseudomonas aeruginosa
were selected for the test . These studies showed
antimicrobial effects against
Staphylococcus aureus, Escherichia coli
, and
Pseudomonas aeruginosa
.
C. officinalis
leaf extract reduced experimentally
induced inflammation in mice. Degrees of anti-inflammation were evaluated
with the various concentrations of
C. officinalis
leaf extract. During the
experiment, mice were divided into seven groups with five mice of each group.
Group I (negative control) received no treatment. Group II, III, IV, V, and VI
received cream containing the extract at 0.0%, 1.0%, 2.0%, 3.0%, and 4.0%,
respectively. Group VII (positive control) received standard medication, 1.5%
calamine. Among mice with UV wounds, a cream containing 2% of the leaf
extracts significantly speeded healing, whereas in 1% carrageenan-induced
inflammatory mice, a cream containing 3% of the leaf extract significantly
speeded healing.
Key words
:
Calendula officinalis, cream, anti-inflammation healing, antimicrobial. | en_US |
