| dc.description.abstract | This study aimed to identify target compounds and their biological activities
including anti-oxidant, anti-diabetic and anti-cancer activities of extracts from
Desmodium heterophyllum. Two pure compounds which are ß-sitosterol and Dpinitol were isolated and purified from methanol extract. Anti-oxidant activity
was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging
assay and results showed no significant value in extracts and compounds except
DH-02 with IC50 value at 24.17 µg/ml. To evaluate anti-diabetic activity, in vitro
enzyme alpha-glucosidase inhibition assay was applied. TE, EE, F-02, ß-sitosterol
and D-pinitol expressed potential with IC50 as 336.98; 72.55; 136.32; 144.75
and 25.18 µg/ml, respectively. The anticancer activity was evaluated by RSB
assay with four cancer cell line Hep G2, HeLa, NCI H460 and MCF-7 but no
significant result was found from this assay.
Key words: Desmodium heterophyllum, , β-Sitosterol, D-pinitol, DPPH, alphaglucosidase, RSB, Hep G2, HeLa, NCI H460, MCF-7. | en_US |
