| dc.description.abstract | Curcumin (Cur), a natural polyphenolic compound extracted from the rhizome of the herb
Curcuma longa exhibits low anticancer activity in vivo due to its poor aqueous solubility
and instability. As Gold nanoparticle (AuNPs) have been proven to be an effective delivery
system with few side effects for anticancer drugs, in this study, functionalized gold nanoparticles
was used as drug carrier to improve the hydrophilic and bioavailability of Curcumin.
Polyvinyl pyrrolidone (PVP), a common used water soluble polymer and Chitosan a “green”
polymer which derived from crustacean shells were utilized to functionalize the AuNPs. The
particles were characterized by UV-visible spectroscopy, transmission electron miscroscopy
(TEM), transmission electron microscope (TEM), fourier transform infrared spectroscopy
(FTIR). The results indicate that curcumin was successfully conjugate to functionalized
AuNPs and the conjugated curcumin was soluble in water. The in vitro cytotoxicity
evaluation of AuNPs conjugate Cur against MCF-7 cancer cell line was measured by SRB
method.
Keywords: Gold nanoparticles, Curcumin, bioavailability, cytotoxicity. | en_US |
