| dc.description.abstract | Conyza canadensis (C. canadensis) ((L.) Cronquist) has been used as medicinal
herb in many countries. The antifungal activity of C. canadensis which was extracted
by different solvents including ethanol, ethyl acetate and n-hexane was examined
by using agar well diffusion method and minimum inhibitory concentration method.
Two fungal pathogens used to determine the bioactive activity of these extracts
were Candida albicans (C. albicans) and Trichosporon insectorum (T. insectorum).
Among these three extracts using different polarity solvents, the antifungal activity
of C. canadensis extracted with ethyl acetate showed the highest antifungal activity
against both tested fungal pathogens. Conversely, the extracts with ethanol and nhexane didn’t show any activity towards the tested fungi in the agar well diffusion
experiment. C. canadensis extracted with ethyl acetate showed its high effectivity
against T. insectorum with 45.33 mm of inhibition zone, antifungal activity was
lower to C. albicans which was about 25.33 mm of inhibition zone. Minimum
inhibitory concentration (MIC) of ethanol, ethyl acetate and n-hexane extract
against C. albicans were 250, 15, and 500 mg/ml, respectively. MIC values to T.
insectorum were better in ethanol and ethyl acetate solvents than which to C.
albicans. The particular MIC values of extracts in ethanol, ethyl acetate and nhexane against C. albicans were 63, 8 and 1000 mg/ml, respectively.
Keywords: C. canadensis, C. albicans, T. insectorum, agar well diffusion, minimum
inhibitory concentration, ethyl acetate, ethanol, n-hexane | en_US |
