Antioxidant and cytotoxicity activities of glinus oppositifolius

Abstract

Glinus Oppositifolius has been used as anherbal plant and popular cuisine in the South of Vietnam for a long time. The aim of this study was evaluating thebiological activities of this traditional plant. In the results, it showed that there arethree pure compounds including quebrachitol (GO04),apigenin (GO05), β- Sitosterol-3-O-β-glucopyranoside (GO01) were isolated from the methanol extract of Glinus Oppositifolius collected in Phu Yen Province of Vietnam. Their structures were elucidated by NMR (1D and 2D-NMR). Methanol and ethanol extract were evaluated cytotoxicity against the HepG2 cancer cell line (SRB method, compared to standard Camptothecin with IC50< 0.07 µg/mL) and lung NCI – H460 cancer cell line (SRB method, compared to standard Camptothecin with IC50< 0.01 µg/mL) which resulted to have a low cancer cell line. Moreover, the antioxidant of 3 pure compounds and plant extracts (GHex, GEt and GMet) also carried out to compare the antioxidant activity with sample curve (Vitamin C). Keywords: Glinus Oppositifolius, quebrachitol, apigenin, β-Sitosterol-3-O-β- glucopyranoside, DPPH, HepG2, NCI-H460, SRB.