| dc.description.abstract | The aim of the research was to develop and evaluate Nano silica carrier for loading drug. In this project, nano silica carriers were provided with a stable system with suitable size particle that enhanced drug trigger and then they were converted into solid nano-scale nanoparticles by using freeze drying process. Drug delivery system (DDS) through nano silica carrier is promising field to achieve control release with enhances bioavailability. The qualities of the DDS by silica depended on the efficiency of drugs which were carried by the DDS, the biocompatibility of DDS, the pattern, particle size, clarity, conductivity and pH value were also important parameters that strongly affect the DDS. These mesoporous silica nanoparticles MSNs synthesized could be used as an effective drug controlled release system for biomedical applications, especially for long-term drug delivery. Porous nanosilica (PNS) has been attracting a great attention in fabrication carriers DDS. However, unmodified PNS-based carriers exhibited initial burst release of loaded bioactive molecules, which might limit their potential clinical application. In this study, the surface of PNS was conjugated with 3-glycidoxypropyltrimethoxysilane (3GPTMS), Hydrazine and Doxorubicin(DOX). In fact, PNS was developed by conjugating the particle in order to increase the efficiency of load drug. The modified PNS was successfully formed with spherical shape, with the approximate diameter from 40 to 50 nm, which can be determined by using transmission electron microscopy (TEM). DOX was efficiently trapped in the PNS-3GPTMS-Hydrazine-Dox and slowly released into phosphate buffered saline (PBS) without any initial burst effect. The results proved that PNS-3GPTMS-Hydrazine-Doxorubicin had great potential as a novel nano-carriers for anticancer drug in cancer therapy.
Keywords:
Porous silica nanoparticles
pH trigger
Drug delivery system | en_US |
