Investigate on conserved sites and correlated mutation sites of hemagglutinin through evolutionary of influenza a H1N1 virus

Abstract

The first popular subtype H1N1 of Influenza A virus has caused historical fatal pandemic about 100 million human deaths recorded. Hemagglutinin (HA), is the major influenza antigen inducing neutralizing antibody responses viral infection, has been studied long-term. In the detail study, highly conserved sites are belonging to the same phylogenic group, promising targets for universal vaccine design. However, the conserved sites have updated frequently to check if it still exists. Thus, the investigation of mutated HA is also significant to understand how its transform through periods. Because the HA domains of each subtype have differed through the periods during natural infection or influenza vaccination. Basic protein investigation is the hope to identify correlated mutated residues and conserved sites of surface hemagglutinin of influenza A H1N1 virus and it is able to determine specific-sites of the protein in epitope and function. Keyword: Hemagglutinin Influenza A Conservation Variation