| dc.description.abstract | Poly (ethylene glycol) methyl ether-chitosan (mPEG-chitosan) as pH-sensitive nanogels was synthesized for multiple drug delivery. The formation of mPEG-chitosan was characterized by Fourier transform infrared (FT-IR) and Proton nuclear magnetic resonance (1HNMR) analysis. The morphology and size of mPEG-chitosan nanogels were revealed by Transmission electron microscopy (TEM), the mean particle size of drug-loaded nanogels was nearly spherical in shape with 35 to 40 nm in diameter, which is the ideal size for evading reticuloendothelial system (RES) in vivo. High-performance liquid chromatography (HPLC) was applied to determine the mPEG-chitosan on drug-carrying and drug-releasing efficiencies, the critical concentrations were 45% paxlitaxel (PTX), 10.1% 5-Fluorouracil (5-FU), and 30% PTX and 5.6% 5-FU loaded nanogels. To be affected by aqueous medium containing PBS and Tween 80 (2% v/v), mPEG-chitosan were released for 12 h. These results showed the meaningful potential of mPEG-chitosan nanogles as DDS for further confirmed by the in vivo anticancer evaluations.
Keywords: Nanogel, 5-Fluorouracil, paxlitaxel, poly (ethylene glycol) | en_US |
