| dc.description.abstract | In the field of transplants and heal bone defects, the injectable hydrogel composite is considered potentially in ability to heal and regenerate damaged bone tissue. Hence, this study will focus on the possibility of mineralization and bone tissue regeneration ability of injectable chitosan / gelatin hydrogel, which is capable of forming a mixture injectable biocomposite when adding biphasic calcium phosphate (BCP) 10%wt in nanoparticle rod shapes. BCP is an inorganic mineral component promoting mineralization when biocomposite was soaked in stimulates body fluid (SBF). The creation of the mineral apatite of biocomposite after soaked in 28 days was characterized by using x-ray powder diffraction (XRD) and scanning electron microscopy (SEM). Besides empirical assessment of mineralized material had be done in vitro conditions, there must be a possibility experimental mineralization, cell compatibility, non-inflammation, and linking with the surrounding tissues, to form new bone tissue replaces damaged bone tissue; therefore, designed experiments on living rabbits body with hydrogel composite samples were prepared. Results had be harvested after about 16 weeks’ time, which were analyzed volumetric, bone density formed by methods Micro computed tomography (micro-CT). Results from apatite mineralization suitable for bone regeneration and implant materials experiments on rabbits showed bone harmony as well as the ability of a material link with the surrounding bone tissue to form new bone tissue replacement tissue bone damaged were great.
Key words: gelatin, chitosan, BCP nanoparticle, mineralization, bone regeneration. | en_US |
