| dc.description.abstract | In this work, the improvement conditions of the oxidation of 1,2-dihydro-2,4,6-
triphenyl-1,3,5-triazine with different N-halosuccinimide reagents, solvents and
concentrations were investigated at room temperature. The product was then
characterized by NMR spectrometry at 500 MHz in CDCl3. The results revealed that
the 1:1 equivalence of starting reactant with NCS or NBS in DCM and NIS in DMSO
were the best conditions for the next investigation on different reagent
concentrations. All three oxidant reagents with two times concentration higher than
the starting material had excellent yields and short reaction time. Therefore, the best
condition for further research was the oxidation of 1,2-dihydro-2,4,6-triphenyl-1,3,5-
triazine by NCS (1:2) dissolved in DCM due to its effective result (97%), simple
procedure, inexpensive and stable reagent. Besides, the expected product’s antibacterial activities were evaluated on four distinct bacteria: Staphylococcus aureus,
Cutibacterium acnes, Escherichia coli, and Salmonella typhi by disk diffusion and
minimum inhibitory concentration (MIC) methods. As a result, this agent expressed
its anti-bacterial properties on all four bacteria, with the MIC value ranging from 1.0
mg/mL to 4.0 mg/mL. | en_US |
