| dc.description.abstract | Vietnamese pepper is of good quality, exported to many parts of the world,
bringing income to people, but it is still not sustainable. With the desire to
better exploit the value of pepper and stabilize the source of income for
farmers, the project wants to create applied products from pepper, namely (1)
nano-products of pepper essential oil with neem oil, and another product is
(2) piperine-curcumin soft capsule. Pepper essential oil is obtained from
the peel of pepper which has many health values. Nano neem pepper essential
oil is used as a biological product to prevent and kill pests and diseases for
crops. Piperine obtained from pepper skullcap enhances the potency of many
compounds such as curcumin. Curcumin is the active ingredient in turmeric,
supporting the treatment of stomach ulcers, anti-inflammatory, preventing
cancer, ... but difficult to absorb. Curcumin-piperine oral tablet can increase
absorption and optimize effectiveness. The goal of the project was to explore
and determine the most suitable formula of curcumin and piperine dissolved in
Sacha Inchi oil, as well as to investigate into the influencing factors of the
surrounding environment on the system's long-term stability. Since then, the
formula has been developed and used to produce the soft gels of curcumin in
Sacha inchi oil containing piperine. The study results that co-solvents influence
directly on the solubility of curcumin in the Sacha Inchi oil. This result can be
used for further investigation about the stability of the solution and the ability
for preserving the active ingredients. On another hand, the nanoemulsion will
be fabricated specifically using phase inversion temperature method (PIT) with
polysorbate emulsifiers of different values of hydrophobic-hydrophilic balance
(HLB) and different ratios of neem oil and black pepper essential oil in the oil
phase with polysorbate 80 (Tween 80). The stability of this nano emulsion
system is subsequently evaluated following several factors including time,
temperature, and storage conditions. At the final stage, the nano emulsion of
Pepper and Neem was fabricated for the application as the biopesticide based
on their bio-pesticidal effects. The study results revealed that the system
achieved the optimal nanoemulsion following the ratio between neem oil and3
black pepper essential oil in the oil phase is 5:1 and the ratio between
surfactant and oil is 10:3 with an HLB value less than 16 and the best storage
condition is at room temperature and away from direct sunlight. The study is a
part of Project of research and application for technology development
provincial of Ba Ria – Vung Tau province: “Research on production of high –
value products (Piperine and Oleoresin) as raw materials using in
pharmaceuticals and supplements from Black pepper in Ba Ria – Vung Tau”. | en_US |
