Synthesis of fluorinated derivative from terpenoid

Abstract

The objective of the thesis project was to hydroxyfluorinate dipterocarpol derivatives to produce a fluorinated compound. Dipterocarpol was extracted from resin with a low yield of 14% prior to its reaction with CrO3 to create lactone at a rate of around 62.8%. The lactone is then converted to alcohol, alkene, and fluorinated derivatives with the yield of 38.28%, 71.08%, and 30.39%, respectively. In addition, mCPBA might produce an epoxide ring from alkene derivatives of lactone under ideal circumstances and HF was used to open the epoxide ring. Therefore, the reaction was successful with a low yield. The synthesis of the fluorinated derivative is an entirely novel reaction with the starting material Dipterocarpol. Consequently, the topic must explore several circumstances, including catalysts, agents, temperature, duration, and reaction rate. The structures of all produced compounds match to those shown in 1H NMR and 13C NMR spectra