| dc.description.abstract | The topic was to perform hydroxylation of the dipterocarpol and lactone –
dipterocarpol to obtain the most polar compound. Lactone was synthesized from
dipterocarpol obtained roundly 64.45%. Meanwhile, dipterocarpol was extracted
only about 15% because of high impurities and loss during crystallization and
recrystallization stages. Also, dipterocarpol processed to alcohol and alkene
derivatives’ formation totally with a high yield which was 95.59% and 78.78%,
respectively, and the hydroxylation step was also successful. However, due to
three double bonds on dipterocarpol’ structure, the selectivity for the desired
product was hard to isolate. On the contrary, about the lactone case, lactone
reduced into two alcohols at the first step because of its structure, but the yield
was not expected as in dipterocarpol’s case (37.37%) due to loss during workup
stage. In the dehydration step, only one alkene was formed led to a yield of
75.25%. During the hydroxylation step, lactone, which gave a new compound that
had one hydroxyl group and one ester group with the mCPBA ring, was a good
sign in producing a more polar compound than dipterocarpol. Nevertheless, the
yield was low at around 17.65% due to impurities. All of the synthesized
compounds’ structures are corresponding to the structures shown in 1H NMR and
13C NMR spectra. | en_US |
