Synthesis Of Polyethylene Glycol Triterpenoid Conjugates

Abstract

The aim of the project was to synthesize conjugates between the polymer polyethylene glycol with triterpenoid derivatives of dipterocarpol. Of 4 of the products predicted to be synthesized from the 2 types of Polyethylene glycol (PEG400 and PEG6000), 1 was successfully purified and characterized. The intermediate products between succinic anhydride and dipterocarpol derivatives were able to be synthesized, yet there were 2 main products were achieved after the reactions between the intermediate products and different kinds of polyethylene glycol (PEG) and only one was successfully isolated. Both products of the reactions between 2 types of PEG and succinic dipterocarpol oxime were unable to be formed due to the instability of the reactant.