| dc.description.abstract | In situ crosslinking hydrogels have increasing rapidly as an interesting topic in the field
of biomaterials, particularly in the context of the newly emerging 3D bioprinting technique.
This is due to the fact that researchers are hopeful that these hydrogels will soon be able to
satisfy the massive demand for organ and tissue transplants, even the more complex ones. In
this study, a novel hydrogel system via self-crosslinking was fabricated and analyzed. It was
an imine crosslinking hydrogel that was based on N,O-carboxymethyl chitosan (NOCC),
oxidized xanthan gum (OXG), and low-cost domestic component. Different hydrogel
fabrication parameters, such as varying the temperature and making adjustments to the
volume ratio of the solvent, were studied. On the modified materials, a Fourier transform
infrared spectroscopy (FT-IR) analysis and an assessment of the precursor solution viscosity
were carried out. On the hydrogel samples, a scanning electron microscope (SEM) was used
to analyze the cross-sectional surface morphology, equilibrium swelling degree, and in vitro
degradation behavior. The FT-IR measurements provided conclusive evidence that every
component had been altered. The study of reaction efficiency, solution viscosity, hydrogel
morphology, swelling, and degradation behavior revealed how NOCC or OXG component
contributed towards hydrogel characteristics. Additionally, the study revealed that the
beneficial effect of raising total polymer fractions should be considered despite the difficulty
of homogeneous mixing. It is difficult to graft as well as determine the carboxymethyl group
onto the chitosan backbone while synthesizing hydrogel samples; however, the results
obtained from the raw materials and hydrogel samples are still reliable, and they reached the
parameters are satisfactory showed desired hydrogel properties for applications in the field
of tissue engineering. Overall, gaining a fundamental comprehension of the process of
hydrogel modulation will assist in the production of a hydrogel composite that is superior in
terms of its performance in specific applications. | en_US |
