| dc.description.abstract | In recent years, there has been a growing interest in using bacterial cellulose for biomedical applications
thanks to its higher purity and more desirable properties. Regarding hemostatic application, however, most
studies on NO2-based oxidized bacterial cellulose (OBC) have focused on its use as a coating agent on
another polymer substrate. In this study, we aimed to fabricate a hemostatic dressing of OBC itself by
oxidizing an intact bacterial cellulose pellicle and investigating different reaction parameters, including
pellicle dryness and oxidation period. Macroscopic observation showed that partially dried pellicles
maintained better structural integrity than completely dried pellicles. Fourier-transform infrared
spectroscopy confirmed the change in the chemical composition of all OBC samples through the appearance
of carboxyl groups. Although scanning electron microscope (SEM) images revealed no significant
difference in cellulose fiber morphology between OBC membranes and pristine membranes, the tensile
strength of all OBC samples was lower than the unmodified one. Along with the Chitosan oligosaccharides
(COS) loading to improve the anti bactericidal of the membranes. The antibacterial property was evaluated
by using the agar disk diffusion method against gram-positive and gram-negative bacteria. Moreover, the
study also investigated the hemocompatibility of materials to show that the OBC-COS membranes could be
a promising material for application in excessive bleeding treatment with further improvement and
exploration | en_US |
