| dc.description.abstract | Passiflora Foetida Linn (P. Foetida) is owned as a typical traditional herb for treating
anti-anxiety and insomnia. Although there have been a few studies on the application of
P. Foetida in medicine, such as antibacterial, anti-inflammatory, or pain relief, its role in
the application of sedative and anti-anxiety treatment in Vietnam remained
underexplored or has been modestly studied and thus requires them to be scientifically
validated. This work mainly focuses on the total extract of the dried sample with
Ethanol, and both qualitative and quantitative analyses of the leaf extract were carried
out. Lastly, the ethanolic section was evaluated in mice by elevated plus maze (EPM)
evaluated the ethanolic extract in mice. Specifically, the total flavonoid content was
determined using aluminum chloride, whereas the total phenolic content was assessed
using the Folin-Ciocalteu assay. Meanwhile, the anti-anxiety activity of the plant
extracts was evaluated using an elevated plus maze (EPM). As a result, the preliminary
phytochemical screening indicated the presence of saponin and alkaloids in the ethanolic
P. Foetida extract. In contrast, phenolic compounds and flavonoids were not present.
Next, the total phenolic compound content was 177.3 ± 0.35 (mg GAE/g dried extract),
indicating a medium level of phenolic compounds in the plant extract. The total
flavonoid content was 61.15 ± 0.884 (mg QE/ g dried extract). Finally, EPM affected
SWISS mice but at a slight level, and the ethanolic extract was expected to have
anti-anxiolytic properties at higher doses. | en_US |
