| dc.description.abstract | The main purpose of this project is carrying out the alpha keto halogenation reaction in the acidic
condition to synthesize the halogen derivative of triterpenoid compound. Although this reaction
has been used to create organohalides in many previous reports, there has been no research using
this reaction with a complex structure as the triterpenoid compound. Therefore, this project
desires to apply this reaction into creating halogen derivatives for a chosen triterpenoid structure
to detect whether this reaction works or not. The collected result indicates that the Fluorination
works well with high yield (38.25%) less byproduct. The Iodination also works but with lower
yield (16.67%) and the unstable product. The Chlorination gives expected results on TLC plates
but the product is too little to be isolated. The Bromination does not occur although the reaction
time is long. The 1H NMR and 13C NMR spectrum of Fluorine derivative appears clearly the
sign of CH – F and C – F. The 1H NMR and 13C NMR spectrum of Iodine also report the
existence of CH – I and C – I, but the product of iodination is not stable. | en_US |
