Evaluating The Ameliorative Role Of Polyscias Fruticosa Leaf Extract- Supplemented Diets In Aluminum Chloride Induced Model Of Neurotoxicity In Drosophila Melanogaster

Abstract

The Vietnamese employ Polycias fruticosa leaves with antioxidant properties to aid in the treatment of neurodegenerative disorders like Alzheimer's. The study is aimed to evaluate the potent antioxidant activity of P. fruticosa leaf extract for neurological treatment in in-vivo conditions. The effect of consumption of P. fruticosa leaf extract was justified using on AlCl3-induced model of neurotoxicity Drosophila melanogaster flies with survival assay, climbing assay, olfactory learning assay, and malondialdehyde (MDA) and glutathione (GSH) level as biomarkers. D. melanogaster was exposed to a concentration of 1.0, 2.0 and 4.0 mg/mL of the leaf extract. I t was suggested under toxic conditions, the leaf extract can increase longevity for flies as well as improve the flies' behavior and biochemical parameters. For all tests, 1.0 mg/mL had the tendency to express the best when improving the ability of movement and remember as well as play an important role in decreasing the MDA level and increasing GSH level in flies’ homogenates. The obtained results pointed to the potential of P. fruticosa extract used for prevention and possible treatment caused by aluminum chloride, but it still needs further investigation.