| dc.description.abstract | Diet, particularly the quantity of sugar consumed, partly influences the organism's development and
longevity. In this study, high-sucrose diets (HSD) were constructed on a fruit fly model to observe
adverse cues on the organism’s development and lifespan, including phenotypic changes related to
diabetes and oxidative stress. High-sucrose diet (30% and 45%) slowed larval and adult fly
development, along with a sharp decrease in the number of larvae pupating and hatching flies.
Metabolic parameters such as weight and size of all three morphologies also decreased with increasing
sucrose concentration in the diet. Hemolymph glucose concentration in adult flies showed reduction
during 7 days of HSD feeding but increased after a 14-day period of exposure. The effect of a high
sucrose diet was also assessed using sex differences, weight and glucose concentration investigations
revealed that males were better able to adapt. However, biomarkers demonstrated that males were
more likely to develop oxidative stress in adult flies given HSD for 14 days. Taken together, these
results demonstrated that the consumption of a high-sucrose diet developed detrimental effects on the
development and metabolic regulations in Drosophila melanogaster. This study might pave the way
for future research into the mechanisms of diet-induced metabolic disorders. | en_US |
