| dc.description.abstract | Wound healing presents complex biomedical challenges, particularly in the context
of chronic wounds and impaired healing mechanisms. This study explores the potential of
electrospun membranes composed of polycaprolactone (PCL) and poloxamer 407 (POX),
enriched with nano curcumin and tamanu oil, as advanced wound care solutions. Through
a comprehensive research framework, including fabrication, characterization of
morphology and density of coated solution onto the fabricated membranes, characteristics
of the prepared membranes were demonstrated and evaluated through standard
experimental methods. In vitro antibacterial assay, in vivo evaluations of mouse model and
gene expression analysis indicated the efficacy of these membranes. Results revealed that
higher concentrations of tamanu oil contributed to enhanced coating density and improved
wound healing efficacy. Controlled release kinetics of curcumin and tamanu oil from the
membranes were demonstrated, along with significant antibacterial properties against
Staphylococcus aureus and Pseudomonas aeruginosa. In vivo studies on a mouse model
demonstrated accelerated wound closure, tissue regeneration, and inflammation reduction,
particularly with membranes containing higher concentrations of tamanu oil. Histological
and gene expression analyses provided mechanistic insights into the enhanced wound
healing process. Overall, this study highlights the potential of electrospun PCL/POX
membranes coated with nano curcumin and tamanu oil as promising candidates for
advanced wound care strategies, with implications for the development of effective
therapies for chronic and non-healing wounds. | en_US |
