| dc.description.abstract | This thesis primarily delineates the fabrication process of electrospun membranes
comprising PCL/POX/CIO for antibacterial wound dressings. Within the scope of this thesis, the
membranes underwent comprehensive characterization through various tests and experiments.
The principal objective of this study pertains to the discernment of the supremely efficacious
concentration among the triad of constituents, namely PCL, POX, and CIO. During the
preliminary phase of the characterization stage, the topographical surface morphology was
conducted utilizing SEM. This allowed for the observation of the fiber matrices and the
formations of beads. Consequently, it can be concluded that there is a proportional correlation
between the CIO concentration and the fiber diameter. Furthermore, as the concentration of POX
increased, beads were discovered. Theoretically, as water absorption capacity is one of many
primary criteria for an effective wound dressing product, contact angle and water absorbability
test were therefore performed. The results have strongly emphasized on the role of POX, which
significantly enhances the water absorption capacity as its concentration increased. Despite its
undeniable role, POX was discovered to significantly reduce the mechanical strength of the
electrospun membrane through the tensile test due to bead formations. Furthermore, FTIR was
employed to ascertain the presence of chemical functional groups about the constituent
substances. In order to confirm moisture permeability, MVTR was also performed. Lastly,
obtained membranes were investigated for their antibacterial activity with S.aureus and
P.aeruginosa using the agar diffusion technique. As a result, membranes exhibited good
antibacterial properties in S.aureus, proving that this PCL/POX/CIO membrane has promising
potential in the future. | en_US |
