Manufacturing And Evaluation Of Dip Coating Device For Fabrication Of Coated Transdermal Drug Delivery Microneedle

Abstract

The demand for highly precise and uniform coatings on microneedles (MNs) is growing rapidly due to their increased use in various biomedical applications, including drug delivery, transdermal vaccination, and biosensing. This surge in demand has necessitated the development of more advanced and efficient coating methods to meet the requirements of these applications. However, the existing methods for coating MNs, particularly the manual hand-dipping technique, suffer from several limitations. These include issues related to sterility, coating uniformity, and efficiency. To address these challenges, a novel dip coating device has been proposed and developed in this study. The problem statement revolves around the need for a more controlled and automated coating system that can deliver precise and uniform coatings on MNs. The manual hand-dipping method, while widely used, presents significant challenges in terms of sterility, uniformity, and efficiency.The proposed solution is a dip coating device that utilizes a gas jet drying method for precision coating of MNs. This device incorporates a stepper motor for controlled immersion, ensuring uniform coating thickness.The methods employed in this study include an extensive literature review to identify the limitations of existing coating methods, followed by the conceptualization and design of the dip coating device. Prototyping and iterative testing were then conducted to refine the device's design and performance. The results of this study indicate that the proposed dip coating device offers significant advantages over existing methods. It provides highly precise and uniform coatings on MNs, addressing the issues of sterility, coating uniformity, and efficiency. The device is scalable, cost-effective, and versatile, making it suitable for various biomedical applications. Summarize, the dip coating device represents a significant advancement in the field of microneedle coating technology. It has the potential to revolutionize the way MNs are coated, offering precision, efficiency, and scalability that were previously unattainable with existing methods.