| dc.description.abstract | In chemotherapy, due to the lack of specification and solubility of drug molecules, high doses are often applied to achieve the desired therapeutic effects, leading to unwanted complications and side effects. To address these issues, various drug carriers have been designed and synthesized to deliver therapeutic agents directly to the target sites in the body. In this study, a redox responsive drug delivery system based on a hybridization of mesoporous silica nanoparticle (MSN) and pluronic F127 was fabricated. First, MSN was synthesized by the Stober method and sequently modified with (3-Aminopropyl)triethoxysilane and 3,3-dithiodipropionic acid to form MSN-S-S-COOH. Simultaneously, FI27 was activated using 4-nitrophenyl chloroformate and ethylene diamine to achieve NHa-F127-OH. Then, the MSN-S-S-F127 was achieved by the reaction between the prepared MSN-S-S-COOH and activated NH-F127-OH. Physicochemical properties, drug loading capacity and drug release profile of the obtained MSN-S-S-COOH were evaluated. The results showed that MSN-S-S-F127 was monodisperse spheres with 240.6 nm in hydrodynamic diameter and its loading capacity for Doxorubicin was 7.07%. Especially, MSN-S-S-F127 exhibited redox sensitivity when being stable under physiological conditions and degraded in reduced environment (with 10 mM DTT) through DLS and Zeta potential analysis. The amount of Doxorubicin relcased in reduced environment was significantly higher 23% compared to that in physiological condition 10%. These results demonstrated that MSN-S-S-F127 would be a promissing potential drug delivery system in chemotherapy with effective loading capacity and redox-responsive release behavior. | en_US |
