| dc.description.abstract | The integration of the extraction and derivatization of flavonoids to the Citrus
processing sector offers environmental sustainability and economic benefits.
Naringin, a flavonoid extracted from industrial waste pomelo (Tien Giang, Vietnam)
using a water:ethanol mixture, was subsequently hydrolyzed to produce another
flavonoid known as apigenin. These flavonoids were characterized by NMR
spectroscopy. These flavonoids formed complexes with copper (Cu) in copper (II)
acetate - Cu(CH3COO)2 salt. Identification of these complexes were accomplished
through spectroscopic methods such as UV/Vis and FT-IR, alongside elemental
analysis using F-AAS. Evaluation of the antibacterial activity of these complexes
against S. aureus and E. coli bacteria, compared to a control (chloramphenicol),
revealed enhanced activity upon binding of synthesized flavonoids to Cu. Minimum
inhibitory concentration (MIC) determination via agar dilution assay method,
indicated potent antibacterial activity against two reported bacteria. Particularly, the
obtained results showed that Cu(II)-naringin had a significantly higher antibacterial
activity against two reported bacteria compared to Cu(II)-apigenin, with the data for
Cu(II)-naringin being more than four times greater. | en_US |
