| dc.description.abstract | Injectable hydrogels are attractive biomaterials for various biomedical
applications. A wide variety of naturally occurring polymers, including polysaccharides,
are employed in hydrogel production. Among these, alginate is the most significant and
widely utilized polysaccharide due to its non-toxicity, biodegradability, and
biocompatibility. Hydrogel production in situ has been extensively researched using the
horseradish peroxidase (HRP)-mediated cross-linking process, and hydrogen peroxide
(H2O2) catalytic hydrogelation systems have garnered much attention due to their easily
handled and controlled gel characteristics. In this study, we introduce a novel approach
to create a dual-crosslinked alginate hydrogel without the direct addition of H2O2 for
HRP-mediated hydrogelation, in which calcium peroxide (CaO2) acts as H2O2 sources.
As we expected, the resultant hydrogel was predicted to have improved mechanical
properties, cytocompatibility and antibacterial properties, which are advantageous in the
treatment of wounds and other medical applications. The structure of synthesized
hydrogels is evaluated using different techniques such as 1H-NMR spectroscopy, FTIR,
and UV-Vis spectroscopy. In conclusion, the dual-crosslinked injectable Alg-TA
hydrogels can be used as a promising platform for various biomedical applications, such
as drug delivery and tissue regenerative medicine. | en_US |
