| dc.description.abstract | It became more important than ever to be able to choose the ‘right embryo’, the
one that is destined to implant. While techniques such as preimplantation genetic
diagnosis, mitochondrial DNA analysis, or secreted protein evaluation have
advanced preimplantation embryo assessment, they are invasive and can pose
risks to the embryo. The timing of the first cleavage has recently emerged as a
reliable, noninvasive marker for embryonic viability. This study examines
embryonic markers of potential and quality during the preimplantation
development of ICSI mouse embryos concerning the timing of the first cell
division. Embryos were categorized into four groups based on their first cell
division timing: 18-20 hours, 20-22 hours, 22-24 hours, and 24-28 hours post fertilization. The results indicated that embryos undergoing the first cell division
at 18-20 hours showed higher efficiency in yielding blastocysts compared to those
dividing at the two-cell stage (82.6% vs. 64.4%, 47.1%, and 31.3%, P<0.05).
Additionally, embryos dividing at 18-20 hours had significantly higher total cell
numbers compared to those at other timings (109 vs. 80, 53, and 39; P<0.05).
These findings provide a simple, accurate, and noninvasive method for embryo
selection, potentially improving the success rates of embryo transfer in assisted
reproductive technology (ART). | en_US |
