| dc.description.abstract | Fusobacterium nucleatum ATCC 25586 is one of the most prevalent parasitic bacteria
today; therefore, lots of research was done to find the best ways to eliminate
Fusobacterium nucleatum out of the body when it becomes excessive. However, the
biggest problem with this bacterium is to reduce their quantity, when Fusobacterium
nucleatum colonies have the ability to create biofilm. Therefore, the study focused on
testing the effect of antibiotics on Fusobacterium nucleatum from 9 typical antibiotics for
9 antibiotic groups, including Metronidazole, Clindamycin, Ampicillin, Chloramphenicol,
Spiramycin, Gentamicin, Doxycycline, Ofloxacin, Vancomycin. This objective was
attained by the sensitivity and antibiotic resistance identification of Fusobacterium
nucleatum by 2 methods which were the Kirby-Bauer disk diffusion and the Dilution
method. Contributing to determining the antibacterial levels of antibiotics, preventing
agents, and appropriate antibiotic screening to assist in effectively eliminating most cases
of Fusobacterium nucleatum infection. In addition, Mentha piperita Extract was chosen
to test on Fusobacterium nucleatum as a preventing agent made from natural medicinal
herbs, which are more friendly sources and more attention than chemicals in recent years.
The results showed that Doxycycline is the antibiotic that the most affected
Fusobacterium nucleatum, Ofloxacin, Ampicillin, and Gentamicin have the medium
effect, while Vancomycin, Metronidazole, Clindamycin, Spiramycin couldn't decrease
Fusobacterium nucleatum. The mucoid layer of Fusobacterium nucleatum was removed
under the impact of Metronidazole and Spiramycin, but these antibiotics cannot kill
Fusobacterium nucleatum. Additionally, there was a significant statistical difference in
terms of the viability of bacteria between the Mentha piperita extract and PYG broth, with
Fusobacterium nucleatum concentration in Mentha piperita extract slightly more than in
PYG broth. Finally, these findings help to create the profile of antibiotic sensitivity of
Fusobacterium nucleatum ATCC 25586 and information about Mentha piperita extract
potency on this strain to warn for the prevention in the future. | en_US |
