Genetic Variants Of Sert Gene Between The East Asianl And Vietnamese Populations: Preliminary Study For Researching Depression

Abstract

Depression and anxiety are increasingly prevalent across various age groups, reflecting ongoing developments in the modern world. Recent research in this field suggests that alongside psychological factors, several genetic variants in the human genome contribute to the pathogenesis of depression. This thesis aims to comprehensively analyze genetic variants associated with depression using variant calling processes, focusing primarily on the serotonin transporter protein (SERT) in the Vietnamese population and comparing the findings with East Asian data. The results reveal equivalent ratios of high-frequency variants, which are predicted to be characteristic of both Vietnamese and East Asian populations. Additionally, specific harmful SNPs in individuals from Vietnamese and East Asian populations were identified, providing valuable information for preliminary research. This thesis employs bioinformatics tools and statistical analyses to evaluate the significance of these genetic variations. The findings contribute to the growing body of knowledge on Vietnamese and East Asian populations-specific genetic variations and their potential implications for depression susceptibility and treatment responses.