| dc.description.abstract | Polyscias fruticosa (L.) Harms belonging to the family Araliaceae is widely
cultivated in Vietnam for medicinal and food purposes. Extracts of P. fruticosa
leaves had antipyretic, anti-inflammatory, analgesic, and molluscicidal properties
(Bernard et al. 1998, Asumeng Koffuor et al. 2015), as well as α-glucosidase
inhibitory and antidiabetic activities (Divakar and Bensita 1998, Mai et al. 2007).
This study provides scientific results on the hypoglycemic activity of Polyscias
fruticosa (L.) Harms in order to preserve, develop and effectively exploit this
source of medicinal herbs in the production of drugs with quality, safety, and
reasonable prices that promote people's health. At the same time, take advantage
of the rich source of medicinal herbs in Vietnam. One therapeutic approach for
treating diabetes is to decrease postprandial glycemia by inhibiting enzymes
responsible for carbohydrate hydrolysis, such as α-glucosidase and α-amylase as
well as hypoglycemic effect in alloxan induced diabetic mice. α-amylase inhibitory
activity was found at concentration from 5 to 200 µg/mL (IC50 = 24.9 ± 0.24
µg/mL) while acarbose was found at 10 to 100 µg/mL (IC50 = 74.19 ± 1.48
µg/mL). α-glucosidase inhibitory activities was found that at concentration from
200 to 1000µg/mL (IC50 = 921.47 ± 13.78 100 µg/mL) while acarbose was found
at 25 to 1000 µg/mL (IC50 = 59.87 ± 5.98 µg/mL). The oral administration of P.
fruticosa extract at doses ranging from 50 mg/kg to 1000 mg/kg on alloxaninduced hyperglycemic mice, given the result that at 100mg/kg the extract exhibit
a 58% decrement in blood glucose level in 20 days, whilst oral administration at
dose 250mg/kg has the highest hypoglycemic effect in with a 68% decrement in
blood glucose level. | en_US |
