| dc.description.abstract | Musa balbisiana fruits is an important and commonly used plant for its medicinal
and pharmacological properties. The present study aimed to evaluate in vitro antiurolithiatic, antibacterial, and anti-inflammatory activities of crude and
fractionated extracts of M. balbisiana fruits. Results showed that crude 45%
ethanol extract by hot extraction method had better anti-urolithiasis, antibacterial,
and anti-inflammatory activities than crude 45% ethanol extract by cold
maceration method and crude water extract by decoction method. Some M.
balbisiana fruit extracts had the greater potency in anti-urolithiatic activity
compared to positive control. Chloroform fraction had the highest ability against
calcium oxalate crystals formation with an IC50 value of 22.04 ± 1.09 µg/mL, which
was comparable with sodium citrate (202.08 ± 18.46 µg/mL). In the active in
against crystals aggregation, n-hexane fraction had the highest activity with an
IC50 value of 414.77 ± 10.85 µg/mL, whereas IC50 value of sodium citrate was
1390.33 ± 92.66 µg/mL. Furthermore, crude and fractionated extracts presented
anti-inflammatory activity through inhibition protein denaturation and red blood
cells membrane stabilization. Simultaneously, the crude extracts exhibited the
ability to against E. coli, P. aeruginosa, and S. aureus. Taken together, the present
study had demonstrated that M. balbisiana fruits has properties that support
urolithiasis disease. | en_US |
